About Me
I am a final-year PharmD candidate researching the molecular biology of human dermal fibroblasts, with a focus on extracellular matrix signaling and skin regeneration. My thesis combines wet-lab cell culture and qPCR analysis with a self-built network pharmacology pipeline in Python — bridging bench science with computational drug discovery. I am currently pursuing PhD opportunities that integrate computational and AI-driven approaches with translational research, including their emerging applications in pharmaceutical sciences.
َAI in Pharmacy
Dermal Fibroblasts
Skin Aging
Network Pharmacology
Bioinformatics
Regenerative Medicine
Skills
Technical Skills
Python & Machine Learning
Network Pharmacology & Bioinformatics
Wet-Lab Techniques (Cell Culture, qPCR, MTT)
Research Skills
Scientific Writing & Publishing
AI-Assisted Research & Web Development
Project Management & Coordination
Education
Doctor of Pharmacy (PharmD)
Tehran Medical Sciences, Islamic Azad University, Tehran, Iran · 2020 – 2026
Thesis Details
Thesis Title: “Synergistic Effect Study of Magnesium Ascorbyl Phosphate (MAP) on the Quality of Polydeoxyribonucleotide (PDRN) Effects on Human Dermal Fibroblast (HDF) Proliferation and Vitality”
Design: Four-group in vitro comparison (control, MAP, PDRN, MAP+PDRN combination) in primary human dermal fibroblasts. Outcome measures included cell viability/proliferation (MTT) and gene expression (COL1A1, MKI67 by qPCR).
Duration & Role: Approximately one year. Independently conducted experimental design, cell culture, MTT viability assays, data analysis, and manuscript preparation; qPCR was performed with the technical assistance of the laboratory manager, under the supervision of Dr. Hamid Reza Ahmadi Ashtiani.
Status: Single-agent (MAP, PDRN) findings are published; combination-group results are in preparation, supported by a bioinformatics/network-pharmacology enrichment analysis.
Journal Articles
Mechanistic Review of Topical Therapies Targeting Dermal Fibroblasts in Skin Aging and Rejuvenation
Mechanistic Review of Topical Therapies Targeting Dermal Fibroblasts in Skin Aging and Rejuvenation
Akaberi SM, Esfandiyari M, Ahmadi Ashtiani HR.
Journal of Cosmetic Dermatology · 2026 · 25:e70987
Second Author
Immunoinformatics-Based Multi-Epitope Vaccine Targeting Helicobacter pylori
Immunoinformatics-Based Multi-Epitope Vaccine Targeting Helicobacter pylori
Vahdat Khajeh Pasha A, Esfandiyari M, Parnian A, Mahboubi-Rabbani M, Bayanati M.
Cancer Reports · 2026 · 9:e70441
Second Author · Corresponding Author
Divergent Regulation of Proliferation and COL1A1 Expression by PDRN and Magnesium Ascorbyl Phosphate in Human Dermal Fibroblasts
Divergent Regulation of Proliferation and COL1A1 Expression by PDRN and Magnesium Ascorbyl Phosphate in Human Dermal Fibroblasts
Esfandiyari M, Ahmadi Ashtiani HR, Rastegar H, Hedayati M.
Journal of Dermatology and Cosmetic · 2026 · In Press
First Author
Topical Vitamin C and Its Derivatives in Cosmetic Science: Stability, Efficacy, and Formulation Strategies
Topical Vitamin C and Its Derivatives in Cosmetic Science: Stability, Efficacy, and Formulation Strategies
Esfandiyari M, Ahmadi Ashtiani HR.
Journal of Skin and Stem Cell · 2025 · 12(4):e163798
First Author
Manuscripts Under Review
Network Pharmacology and Molecular Docking Reveal Complementary Target Modules Underlying Collagen Suppression by Combined Polydeoxyribonucleotides and Magnesium Ascorbyl Phosphate
Network Pharmacology and Molecular Docking Reveal Complementary Target Modules Underlying Collagen Suppression by Combined Polydeoxyribonucleotides and Magnesium Ascorbyl Phosphate
Esfandiyari M, Vahdat Khajeh Pasha A, Ahmadi Ashtiani HR.
Targeting a Q1 journal
First Author
Molecular Mechanisms and Clinical Applications of Caffeine in Skin and Hair Rejuvenation
Molecular Mechanisms and Clinical Applications of Caffeine in Skin and Hair Rejuvenation
Esfandiyari M, Vahdat Khajeh Pasha A, Ahmadi Ashtiani HR.
Targeting a Q2 journal
First Author
Immunoinformatics-Based Multi-Epitope Vaccine Targeting Herpes Simplex Virus-1 (HSV-1)
Immunoinformatics-Based Multi-Epitope Vaccine Targeting Herpes Simplex Virus-1 (HSV-1)
Vahdat Khajeh Pasha A, Esfandiyari M, Mirhassani RS, Abdolghaffari AH.
Targeting a Q2 journal
Second Author
Peer Reviewer — Journal of Public Health and Community Medicine (2026)
Books
Dermal Fibroblasts: From Basic Science to Clinical Applications
Dermal Fibroblasts: From Basic Science to Clinical Applications
Ahmadi Ashtiani HR, Esfandiyari M, Azadbakht A.
Dr. Ahmadi Publications · 2025 · ISBN 978-622-93030-5-4
Second Author
In Press Books
Cosmetic Manufacturing: Establishment, Management and Development
Cosmetic Manufacturing: Establishment, Management and Development
Ahmadi Ashtiani HR, Esfandiyari M, Rastegar H, et al.
Reference Textbook · 2026
Second Author
Basic Biochemistry Laboratory
Basic Biochemistry Laboratory
Ahmadi Ashtiani HR, Ashtari F, Esfandiyari M, Pourahmadi A.
2026
Third Author
Conference Presentations
Argan Oil in Cosmetic Formulations: Bioactivity and Sustainability Considerations
10th Int’l Conference on Agricultural Sciences, Medicinal Plants and Traditional Medicine · Georgia · March 2026
Artificial Intelligence (AI) in Skin Fibroblast Research: Revolutionizing Drug and Cosmetic Development
Int’l Conference on Medicine and Artificial Intelligence in Health Improvement · Germany · August 2025
Mechanistic Insight into the Role of Superoxide Dismutase in Skin Aging: A Novel Approach for Cosmeceutical Application
8th International Congress on BioMedicine (ICB2024) · November 2024
Anti-Aging and Dermatological Benefits of Grape Seed Oil: Insights from Traditional Use to Modern
9th Int’l Conference on Agricultural Sciences, Medicinal Plants and Traditional Medicine · Georgia · August 2025
A Comparative Mechanistic Review of Retinol in Anti-Aging Skincare
12th Int’l Conference on Applied Research in Basic Sciences, Engineering and Technology · Georgia · August 2025
AUNP-12 Peptide Antagonist: Mechanisms and Applications in Immune Checkpoint Blockade and Cancer Therapy
6th Conference on Proteins and Peptides Science & Technology · Iran · November 2025
Anti-Ageing Effects of Rosa Canina (Rose Hip) Extract in Topical Application: A Biochemical and Pharmacological Evaluation
7th Int’l Conference on Agricultural Sciences, Medicinal Plants and Traditional Medicine · Georgia · September 2024
Review and Applications of Borage Oil in Specialized Skin and Hair Products
8th International Congress on BioMedicine (ICB2024) · November 2024
Computational Projects
Network Pharmacology Pipeline for MAP–PDRN Synergy in Human Dermal Fibroblasts
A modular, object-oriented Python pipeline identifying candidate synergistic hub genes through three-way set intersection, with automated Venn-diagram visualization and STRING-ready export.
Network Proximity & Module Separation Engine for Drug-Combination Prediction
A full-interactome network-proximity analysis CLI applying the Menche/Guney/Cheng framework to classify gene-module relationships on the complete human STRING interactome (~19,000 proteins), with degree-preserving permutation testing.